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Fluorouracil (Five-FU) occurs as drug that is used in the coarse of action of cancer. It belongs to the personal of doses known as antimetabolites. These are the pyrimidine analog. Its primary utilise is inside colorectal cancer, in which it has been a constituted form of chemotherapy for decades (platinum-containing drugs come the recent addition).
As a pyrimidine analogue, it is transformed in a cell into different cytotoxic metabolites which are incorporated into DNA and RNA, finally causing cell cycle arrest and apoptosis.
Capecitabine and gemcitabine are prodrugs that are converted to Five-FU in the tissues. It may be administered orally..
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